home › Fuel system › What happens if you take 2 tablets? What happens if you take a lot of pills at once? Clinical picture of intoxication

What happens if you take 2 tablets? What happens if you take a lot of pills at once? Clinical picture of intoxication

Contents of the article: classList.toggle()">toggle

Analgin or metamizole sodium is a classic analgesic with pronounced antipyretic properties, actively used to this day mainly in the CIS countries and the Russian Federation.

The non-steroidal anti-inflammatory drug non-selectively blocks cyclooxygenase and reduces the production of prostaglandins; in addition, it is low cost and is available in free pharmacies.

Excessive use of analgin can cause a number of problems, pathologies and acute conditions. Let's look at what happens if you take a lot of analgin (painkiller) tablets and how to determine an overdose.

How does analgin affect the body?

As mentioned above, metamizole sodium systemically blocks COX, and also slows down the production of arachidonic acid and prostaglandins, at the same time preventing the conduction of pain impulses and increasing heat transfer.

Analgin practically does not irritate the mucous membrane of the gastrointestinal tract, has little effect on water and salt metabolism, but at the same time, in addition to analgesic and antipyretic, it also has an antispasmodic effect of moderate intensity, mainly on the biliary and urinary tract. The therapeutic effect begins to appear 30 minutes after oral administration of the drug and reaches its absolute maximum after 4 hours, after which it is excreted by the kidneys, having previously been metabolized in the liver.

Symptoms of analgin overdose

Let's consider what will happen if you take a lot of analgin (pain reliever) tablets. An overdose of analgin can be either acute (develops 3-5 hours after administration) or delayed chronic (negative manifestations develop after 3 days).

Primary manifestations include:

Nausea and vomiting;
Dizziness, tinnitus and confusion;
General weakness of the whole body;
Tachycardia, sometimes bradycardia;
Paleness of the skin;
Psychomotor agitation;
Hypothermia.,

In severe forms of overdose of metamizole sodium, there is a change in the color of the urine (bloody discharge appears in it), systemic convulsions, including the respiratory muscles, cyanosis, and in some cases, coma.

The chronic type of overdose is characterized by a smooth increase in negative symptoms with multiple disturbances in the gastrointestinal tract (heartburn, bloating, pain, digestive problems, gastrointestinal bleeding), failure of hematopoietic processes (granulocytopenia and agranulocytosis), allergic reactions (edema, urticaria, anaphylactic shock), kidney or liver failure.

First aid for adults and children

In case of an overdose of analgin, the victim should be provided with comprehensive pre-medical care. Classic activities for adults and children include:

Restoring the body after an overdose

After first aid has been provided and a medical team has arrived, in the case of acute analgin poisoning, a decision may be made to hospitalize the victim in a hospital. Doctors at the intensive care unit perform the following treatment and recovery procedures:

Systemic gastric lavage. This is carried out if less than 4-6 hours have passed after taking the drug. Repeat several times if necessary;
Connect to condition monitoring tools. In the event of a severe overdose, the victim requires constant monitoring of vital signs;
Diuresis. Forcing urine flow allows you to quickly remove metamizole sodium metabolic products from the body in general and the kidneys in particular;
Hemodialysis. Aimed at removing toxic breakdown products of analgin from the bloodstream using an extrarenal method;
Drugs. Medications that support the basic functions of the body can be used - anticonvulsants (Relanium), “fast” barbiturates, antihypotonics, antiemetics, and so on. As a supplement, laxatives that activate the elimination of toxins through bowel movements;
Additional therapy. It is used at a late stage of treatment - hepatoprotectors, antibiotics (for the manifestation of secondary bacterial infections), glucocorticosteroids (neutralization of too strong an inflammatory process), antihistamines (combat allergic manifestations), probiotics and prebiotics (restoration of gastrointestinal microflora), droppers with saline and glucose are used, as well as physical therapy.

Consequences of analgin overdose and complications

An overdose of analgin tablets can cause a number of both acute and chronic complications, as well as long-term consequences for the body, requiring additional complex therapy and recovery. Possible consequences:

Urinary system. Diagnosed are oliguria, anuria, interstitial type nephritis, as well as impaired functioning of the kidneys and liver, up to their complete failure in the stage of decompensation;
Allergic and autoimmune reactions. The most common manifestations are urticaria and angioedema. Less commonly - Lyell's syndrome, exudative erythrema of the malignant type, bronchospastic syndrome and anaphylactic shock;
The cardiovascular system. Persistent decrease in blood pressure, thrombocytopenia, leukopenia, agranulocytosis, hemorrhages in the heart and other organs (brain, intestines, kidneys, etc.);
Chronic infectious lesions of the secondary type;
Fatal outcome after an overdose of analgin;
Other obvious and implicit complications caused by systemic intoxication, disruption of basic functions in the acute period (for example, breathing) and malfunction of metabolic processes.

Analgin dosage for adults and children

Let's consider how many analgin tablets you can take at a time. Classic recommended dosages of the drug depending on the age group:

From 10 to 14 years with a body weight of 32-53 kilograms. A single dose of 500 milligrams of metamizole sodium (or 1 tablet). Daily dose – up to 2 thousand milligrams of analgin (or 4 tablets);
From 15 years and older with a body weight over 53 kilograms. A single dose is from 500 to 1 thousand milligrams (1-2 tablets). Daily dose – up to 4 thousand milligrams (8 tablets);
Over 60 years old. The dosage for adults is reduced by 2 times.

Children under 10 years of age with a body weight of less than 32 kilograms are not recommended to use analgin.

Is it possible to die from analgin? The lethal dose of analgin in tablets varies widely and depends on the characteristics of a person’s metabolism, the presence of a number of diseases, the current state of organs (in particular the kidneys and liver), the presence of concurrent use of other medications, the method of drug administration and other factors.

As modern medical practice shows, a high probability of death in the absence of prompt, correct first aid and complex intensive care in a hospital setting occurs with a single use of 5-20 grams of metamizole sodium.

Is it possible to take expired analgin?

Generally accepted medical standards prohibit the use of any medications after their expiration date - they must be disposed of in the prescribed manner. Considering the low cost of the drug, It’s better to throw away tablets or ampoules that have expired, replacing them with new ones purchased from the official pharmacy chain.

However, in some cases (for example, the need to introduce the drug into the body as urgently as possible or a person is in a hard-to-reach place without the opportunity to purchase the drug), the use of expired analgin may be justified.

As clinical practice shows, with careful observance of storage conditions (dark place, completely isolated and sealed packaging, correct storage temperature), metamizole sodium, after the expiration of the period of use recommended by GOSTs, retains its therapeutic properties for another 6-8 years. Moreover, during the process of oxidation and destruction of the substance during very long storage, no obvious toxic compounds are formed.

Health

Despite repeated warnings about the dangers of energy drinks, many continue to drink them, especially young and middle-aged people.

Millions of students and workaholics around the world consume energy drinks or caffeine mixed with an alcoholic drink every day to increase their performance.

But what actually happens to our body when we drink such a drink?

Here is a step-by-step guide explaining the changes in our body, starting from the first 10 minutes and ending with 12 days after drinking just one can of this drink.

It is worth noting that studies have proven that energy drinks, as well as alcoholic drinks, have the same effect on the adolescent brain as the most powerful drugs.

The harm of energy drinks

The first 10 minutes after drinking one can of energy drink

Caffeine begins to penetrate the blood.

Heart rate and blood pressure begin to increase.

In 15-45 minutes

If you drink the drink quickly, after 15 minutes you will feel more alert and more concentrated. But if you drink the drink slowly, this effect will occur in about 40 minutes.

In 30-50 minutes

Caffeine absorption is complete. Your pupils dilate, your blood pressure rises, and as a result, your liver releases large amounts of sugar into your blood. The adenosine receptors in your brain are now blocked and you no longer feel sleepy.

Blood sugar levels spike, causing a spike in insulin. The liver responds to this by converting sugar into fat.

After 1 hour

Your body begins to feel a sudden drop in blood sugar (hypoglycemia). You quickly run out of energy and you begin to feel very tired.

An hour after drinking the drink, you will want to go to the toilet, and you will get rid of the water that was in the drink. This water was enriched with valuable nutrients, but instead of using them for their intended purpose, these substances came out along with the water.

Impact of Energy Drinks

In 5-6 hours

During this time, the amount of caffeine in the body decreased by half. For women taking birth control pills, this period can be up to 10 hours.

In 12 hours

During this time, the human body completely gets rid of caffeine in the blood. Still, the speed of caffeine cleansing depends on many factors, from age to physical activity.

After 12-24 hours

Withdrawal begins. About a day after drinking the energy drink, an unpleasant surprise awaits you. If a person often drinks such a drink, then during this period he begins to feel lethargic, exhausted, headaches and constipation appear.

In 7-12 days

Studies have shown that by this time the body becomes more resistant to regular consumption of a certain dose of caffeine. This means that you will no longer experience the same unpleasant feelings to the same extent.

Read also:

Non-alcoholic energy drinks

Today, anyone can buy a sweet non-alcoholic energy drink, even a schoolchild. While teenagers and older people continue to drink energy drinks and end up in the hospital, advertising continues to talk about how this or that drink invigorates and inspires.

Doctors in many countries, including Russia, have long been warning about the dangers of such drinks, that energy drinks cause problems with the cardiovascular system, potency, can cause insomnia and quickly deplete the body’s energy reserves.

Well, if you mix such a drink with alcohol, the situation gets even worse. This mixture can cause heart rhythm disturbances, seizures, and even kidney failure. It is worth noting that deaths have been repeatedly recorded after consuming energy drinks with alcohol.

Relative benefits of energy drinks

1. For a short period of time, a person receives a boost of vigor and energy.

2. It is possible to choose a drink with a high concentration of caffeine or with a large amount of vitamins and carbohydrates. The former help cope with drowsiness, and the latter increase the level of endurance during physical activity.

3. The vitamins in such drinks can stimulate vital processes in the human body, and glucose can quickly enter the bloodstream and provide energy to the muscles and brain.

4. Thanks to its convenient packaging, energy drinks can be taken with you anywhere and consumed almost anywhere. For some, they can replace a cup of coffee.

5. Most 8-ounce cans of the energy drink contain 80 milligrams of caffeine, which is less than the 400 milligram limit recommended by doctors. Coffee may contain more caffeine than an energy drink (about 300 milligrams on average).

Why are energy drinks harmful?

1. Drinking more than 2 cans of energy drink per day can significantly increase your blood pressure and may also increase your blood sugar levels. The result is hypertension and diabetes.

2. Since deaths after consuming energy drinks have been officially recorded in Europe, in some countries they can only be purchased in pharmacies.

3. The vitamins contained in energy drinks do not form a balanced complex.

4. If a person suffers from a disease of the heart, blood vessels, nervous system, pancreas or liver, then consuming energy drinks will only worsen the situation. The same applies to those who are predisposed to the above diseases.

5. The energy drink itself does not provide energy, but opens the channels of the body where internal resources are contained. As a result of using energy reserves, the body is depleted, a person may experience nervous overexcitation, and with frequent use, fatigue increases, insomnia, irritability appear, a person is more prone to nervous breakdowns and depression.

6. With regular consumption of energy drinks, the body gets used to caffeine and over time asks for a larger dose, and a large dose of caffeine depletes the body and encourages frequent urination, and this in turn removes salts from the body (in a fairly large volume).

7. A large concentration of B vitamins can lead to disruption of the nervous system, increase heart rate, lead to tremors in the limbs and greatly weaken the body.

8. The dose of amino acids taurine and glucuronolactone in one can of energy drink exceeds the daily norm by 500 times. And if you consider that they are consumed together with caffeine, then such a mixture can lead to severe exhaustion of the human nervous system.

9. Caffeine and other ingredients in energy drinks irritate the stomach lining, which means your risk of developing stomach ulcers and gastritis increases.

10. Energy drinks are high in sugar, which means high in calories. Caffeine, as a stimulant, can cause anxiety, nausea, dehydration and increased heart rate.

11. Between 2007 and 2014, in the US alone, the number of people hospitalized due to energy drink use doubled. These data were shared by the Substance Abuse and Mental Health Services Administration (SAMHSA), which is part of the US Department of Health and Human Services.

Composition of energy drinks

* The basis of any such drink is caffeine

There are also extracts of guarana, tea or mate, which also contain caffeine.

Sometimes the manufacturer calls caffeine differently: mateine or theine, but in fact it is the same caffeine.

Other stimulants, such as theobromine and theophylline, which are homologues of the same caffeine.

* Carnitine.

This component promotes the rapid oxidation of fatty acids. This means that it enhances the overall metabolism in our body. As a result, a person’s level of muscle fatigue decreases.

* Taurine.

Some believe that this component of energy drinks, as it accumulates in muscle tissue, leads to improved muscle (and heart) function. However, medical experts claim that taurine has absolutely no effect on muscles. Despite this, in one can of energy drink its volume can range from 400 to 1000 mg. This begs the question: why is it needed then?

* There are also vitamins (in particular B vitamins), such as carbohydrates (glucose, sucrose).

It is worth noting that the body needs B vitamins, and if you are deficient in them, your body will tell you about it. But an excess of these vitamins (which an energy drink can provide) can hardly be considered beneficial for a person.

Special promotion!!!

For all orders of 20 tablets or more today, you will receive a bonus - Generic Viagra 100 mg 5x100 mg (worth 1000 rubles), absolutely free!

If You Take 2 Viagra Tablets

And what If TAKE 5 TABLETS VIAGRA- YouTube

Pills Viagra is known throughout... VIAGRA l WHAT WILL HAPPEN IF DRINK A LOT OF VIAGRA... Dapoxetine What Will Happen If Drink 2 Pills- On the roads of the country If Drink 2 Pills Viagra ... Drink 2 Pills Kamagra What will happen If drink 2 pills... KotokafeMira - If Drink Viagra Moscow If drink...I'm also very interested. What dosage did you take? 2 pills Viagra? If Take Half a Tablet Viagra- Online watch store... What will happen If take VIAGRA immediately after taking it Viagra ... Pills If ... If drink... What will happen If Drink Tablet Viagra Girl What Will Happen If Drink Tablet Viagra... What will happen If Drink Tablet Viagra... Ate the Tablet Viagra Ate a Viagra tablet. Special promotion!!! For all orders from 20 tablets today, ... If Drink Viagra And There Was No Sex... pills Viagra. ... What will happen If drink Viagra? ... Action Video Viagra on girls. What will happen If Drink Two at once Pills Viagra... when Viagra's effect ends. If drink... What will happen If drink two pills ... If Drink Two at once Pills Viagra... Forum Levitra can it happen If drink 2 pills Viagra ... If drink Viagra and... How long will it cost? If Drink One Tablet Viagra Other tablets... If drink... How long does Viagra last? If drink ...

What will happen If drink Viagra?

Paracetamol is a popular, well-known medicine that has antipyretic and analgesic effects. If the dosage regimen is followed, it is considered completely safe, has a minimum of contraindications and side effects.

However, in some cases, namely if Paracetamol is overdosed, the medicine becomes toxic and can provoke the development of very serious consequences.

Overdose can be caused by a number of reasons. In particular, the availability and popularity of the drug itself, which can be presented in pharmacies in different forms and under different names, plays a big role here.

In this regard, many are interested in what will happen if you take 2-4 tablets of Paracetamol? What consequences occur for the body when taking a higher dose? Why does a drug overdose happen and what to do in this case? We’ll talk about all this today on the Popular About Health website:

Experts name several main reasons, in particular:

Taking paracetamol during treatment with other combination drugs containing it.
- Taking pills in combination with alcohol.
- Long-term treatment with the drug.
- Treatment with paracetamol, in the presence of liver pathologies.
- Children often get an overdose due to the presence of tablets in the area of accessibility.

Permissible doses of the drug

For adults:

The maximum dose of the drug should not exceed 4 g of paracetamol. The permissible single dosage is 500 mg for body weights up to 40 kg and 1 g for weights above 40 kg. The course of treatment should not exceed 7 days.

If the daily or single dosage is exceeded, for example, if you drink 2-4 tablets of paracetamol or more, poisoning may occur. For an adult, a dose of 15 grams or more per 1 kg of body weight is considered fatal.

It should be remembered that even a small amount of alcohol can significantly increase the toxicity of paracetamol. What can we say, if you take more pills and alcohol...

For children:

For children over 3 months, the permissible dosage is: Per day -
60 mg per 1 kg of body weight. At one time - 10-15 mg per 1 kg. If exceeded, symptoms of poisoning may occur and the likelihood of side effects increases.

For babies under 3 months, the amount of the drug and the duration of treatment are determined exclusively by the attending physician.

Symptoms of paracetamol poisoning

From 10 hours to 24 hours from the moment of overdose, symptoms of intoxication develop, as with ordinary poisoning:

General malaise, weakness, dizziness;
- lack of appetite, nausea, vomiting, diarrhea;
- painful sensations in the liver area (right hypochondrium).
After 36 hours:
- lowering body temperature, lowering blood pressure;
- severe pain in the abdominal area, increased sweating;
- Jaundice, acute renal failure develops, and the level of glucose (hypoglycemia) and platelets (thrombocytopenia) in the blood decreases.

What happens in the absence of urgent medical intervention? The patient experiences delirium, convulsions and coma. And in case of severe poisoning, irreversible liver failure develops and, as a consequence, death.

What to do?

To avoid serious consequences, you should immediately call an ambulance or emergency room as soon as you become aware of poisoning or its first signs appear.

Before the doctor arrives, experts advise taking an antidote, in particular Acetylcysteine. It is part of many antitussive drugs: ACC, Acestin, or Fluimucil, Vicks Active or Muconex.

The liver is an organ capable of self-healing. Therefore, with a moderate stage of poisoning, a person recovers after a couple of weeks.

Is paracetamol poisoning possible if the permissible dosage is observed??

Doctors warn that you can get poisoned in this case too. In particular, this is possible with simultaneous intake of alcohol, or in the presence of hereditary liver pathologies, as well as during treatment with drugs such as Rifampicin and Isoniazid or while taking paracetamol with anticonvulsants.

Overdose Prevention

When treating with paracetamol, the following precautions should be observed:

You should not take the drug without a doctor's prescription, especially if you have liver pathologies.
- Follow the recommended dosages.
- Do not shorten the interval between doses, which is 4 hours.
- Do not exceed the course of treatment (5-7 days).
- Do not combine the drug with alcohol.
- Keep the tablets out of the reach of children.

During simultaneous treatment with other drugs containing paracetamol, their dosage and course duration should be determined by the attending physician.

Poisoning with paracetamol and other drugs is an urgent and serious problem. Therefore, before starting treatment, it is very important to carefully and thoroughly study the instructions for use. Be healthy!

Popular in the category: